diff --git a/test/py/meson.build b/test/py/meson.build
index 2affdbd491a3..639f173594a8 100644
--- a/test/py/meson.build
+++ b/test/py/meson.build
@@ -4,14 +4,29 @@ if not pycamera_enabled
     subdir_done()
 endif
 
+# If ASan is enabled, the link order runtime check will fail as Python is not
+# linked to ASan. LD_PRELOAD the ASAn runtime if available, or skip the test
+# otherwise.
+
+if asan_runtime_missing
+    warning('Unable to get path to ASan runtime, Python test disabled')
+    subdir_done()
+endif
+
 pymod = import('python')
 py3 = pymod.find_installation('python3')
 
 pypathdir = meson.project_build_root() / 'src' / 'py'
+py_env = ['PYTHONPATH=' + pypathdir]
+
+if asan_enabled
+    # Disable leak detection as the Python interpreter is full of leaks.
+    py_env += ['LD_PRELOAD=' + asan_runtime, 'ASAN_OPTIONS=detect_leaks=0']
+endif
 
 test('pyunittests',
      py3,
      args : files('unittests.py'),
-     env : ['PYTHONPATH=' + pypathdir],
+     env : py_env,
      suite : 'pybindings',
      is_parallel : false)